Stressful life events, 5-HTT genotype and risk of depression
نویسندگان
چکیده
منابع مشابه
The relationship between stressful life events, the serotonin transporter (5-HTTLPR) genotype and major depression.
BACKGROUND Serotonin is a good candidate for major depression. We attempted to replicate the study by Caspi and colleagues [Science (2003) 301, 386-389] which reported a significant interaction between serotonin transporter (5-HTTLPR) genotype and stressful life events when predicting major depression. METHOD We typed the serotonin promoter 5-HTTLPR gene in 1206 male and female twins aged 19-...
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Accumulating evidence has shown that a polymorphism in the promoter region of the serotonin-transporter (5-HTTLPR) modulates neural activation during the perceptual processing of emotional facial expressions. Furthermore, behavioral research has shown that attentional bias for negative information is increased in s allele carriers. We examined the interactions among 5-HTTLPR (including SNP rs25...
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The influence of stressful life events and coping strategies was studied in 50 depressed and 50 non-depressed persons. It was observed that depressives experienced significantly more stressful life events and were also using significantly more avoidance coping strategies as compared to their non-depressed counterparts. The moderate and severely depressed patients were exposed to more stressful ...
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IntroductionThe mood disorders such as depression are the most common mental disorders among individuals. In addition to, girls’ students as a group at high risk are known for developing this disorder. The aim of this study was to investigate the role of perfectionism and stressful life events in predicting disordered depression symptoms among girls’ students. Materials and Methods: This cross-...
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The current study examined whether the personality traits of self-criticism or dependency moderated the effect of stressful life events on treatment response. Depressed outpatients (N = 113) were randomized to 16 weeks of cognitive-behavioral therapy, interpersonal psychotherapy, or antidepressant medication (ADM). Stressful life events were assessed with the Bedford College Life Events and Dif...
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ژورنال
عنوان ژورنال: British Journal of Psychiatry
سال: 2006
ISSN: 0007-1250,1472-1465
DOI: 10.1192/bjp.bp.105.020644